Table 4. Diagnostic performance of single and combination assays.
| Assays | Youden's index | Likelihood ratio | ||
|---|---|---|---|---|
| Positive test (95% CI) | Negative test (95% CI) | |||
| EBV DNA | 0.73 | 4.40 (3.17–5.68) | 0.08 (0.01–0.36) | |
| Architect | VCA IgM | 0.60 | 27.40 (11.39–63.64) | 0.38 (0.19–0.63) |
| VCA IgM and EBV DNA | 0.78 | 4.53 (3.52–5.73) | 0.00 (0.00–0.25) | |
| EBV Antibody and EBV DNA | 0.15 | 1.17 (0.95–1.24) | 0.00 (0.00–1.33) | |
| Liaison | VCA IgM | 0.54 | 29.59 (11.31–74.70) | 0.45 (0.24–0.68) |
| VCA IgM and EBV DNA | 0.78 | 4.53 (3.52–5.73) | 0.00 (0.00–0.25) | |
| EBV Antibody and EBV DNA | 0.13 | 1.15 (0.93–1.22) | 0.00 (0.00–1.48) | |
| Platelia | VCA IgM | 0.25 | 66.75 (10.15–418.62) | 0.75 (0.51–0.90) |
| VCA IgM and EBV DNA | 0.73 | 4.40 (3.17–5.68) | 0.08 (0.01–0.36) | |
| EBV Antibody and EBV DNA | 0.15 | 1.18 (0.95–1.25) | 0.00 (0.00–1.29) | |
Abbreviations: CI, confidence interval; VCA, viral capsid antigen.