Table 1. Clinical and laboratory characteristics of patients diagnosed as having chronic myelomonocytic leukemia according to the WHO criteria.
| 2008 WHO (N=38) | 2016 WHO CMML (N=27) | 2016 WHO others (N=11) | P* | |
|---|---|---|---|---|
| Sex (M:F) | 2.8:1 | 2.9:1 | 2.7:1 | |
| Age | 71±12† | 70±12† | 73±13† | 0.326 |
| WBC (×109/L) | 22.1 (36.6)‡ | 19.7 (58.2)‡ | 35.0 (18.8)‡ | 0.267 |
| Hb (g/L) | 96±21† | 94±19† | 101±25† | 0.411 |
| PLT (×109/L) | 147 (201)‡ | 114 (133)‡ | 263 (139)‡ | 0.005 |
| Blast (%) | 1.2±2.1† | 0.9±1.9† | 1.8±2.8† | 0.075 |
| MON (%) | 22±10† | 24±9† | 14±7† | 0.003 |
| MON (×109/L) | 4.1 (7.9)‡ | 3.8 (10.8)‡ | 4.3 (3.4)‡ | 0.664 |
| EOS (%) | 1 (2)‡ | 1 (1)‡ | 1 (3)‡ | 0.671 |
| BASO (%) | 0.9±1.8† | 0.7±1.9† | 1.4±1.8† | 0.109 |
| NRBC§ | 0.6±1.1† | 0.6±1.2† | 0.6±0.7† | 0.302 |
| M:E ratio | 6.9±5.6† | 6.7±6.2† | 7.4±4.2† | 0.215 |
| BM blast (%) | 3.0 (3.0)‡ | 2.8 (7.0)‡ | 2.2 (2.2)‡ | 0.595 |
| MON (%) | 7.9±6.2† | 8.9±6.7† | 5.4±4.0† | 0.122 |
*The Mann-Whitney U test was used to compare the 2016 WHO CMML group and the 2016 WHO others group; †Values are presented as mean±SD; ‡Values are presented as median (interquartile range); §observed per 100 WBCs.
Abbreviations: CMML, chronic myelomonocytic leukemia; M:F, male to female ratio; WBC, white blood cells; PLT, platelets; MON, monocytes; EOS, eosinophils; BASO, basophils; NRBC, nucleated red blood cells; M:E, myeloid to erythroid; BM, bone marrow.