Fig. 3.
Impact of covariates on steady-state cabozantinib CL/F, Cmin and Cmax relative to a reference White, male, 80 kg, 60 year-old healthy subject. CL/F, apparent clearance, Cmax,ss maximum plasma concentration at steady state, Cmin,ss minimum plasma concentration at steady state, CRPC castrate-resistant prostate cancer, GB glioblastoma multiforme, HAGE a 79-year-old subject, HWT a subject with body weight of 112 kg, LAGE a 36-year-old subject, LWT a subject with body weight of 56 kg, MTC medullary thyroid cancer, RCC renal cell carcinoma