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Enzymatic degradation of vortioxetine. Cytochrome P450 (CYP) 2D6, CYP3A4/5, CYP2A6, CYP2C9, CYP2C19, alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and uridine diphosphate glucuronosyltransferase (UGT) are considered to be the primary enzymes involved in the metabolism of vortioxetine. The intermediates were detected in vitro, but not in vivo. AO aldehyde oxidase
