Vortioxetine is an antidepressant with multimodal activity currently approved for the treatment of major depressive disorder at a dosage of 5–20 mg/day.

Vortioxetine has a favorable pharmacokinetic profile with dose-proportional and linear exposure, moderate oral bioavailability (75%; independent of food), extensive tissue distribution (steady-state volume of distribution of approximately 2600 L), and a long elimination half-life (66 h).

Concomitant therapy is generally well tolerated and dosage adjustments may be required when vortioxetine is co-administered with bupropion or rifampin.