Fig. 2.

Summary of riociguat mass-balance, excretion-pattern, distribution, and clearance properties in humans. All numbers are approximate; sum of percentages is 90–95%, which is the recovery of radiolabel in the human mass-balance study (n = 4). Percentages separated by dashes indicate minimum–maximum observed values in the mass-balance study. Ae _ur amount excreted into urine, Ae _fec amount excreted into bile/feces, CL _sys systemic (plasma) clearance, CL _R renal clearance (via glomerular filtration), CYP cytochrome P450, F _abs absolute bioavailability, M1, M3, and M4 metabolites M1 (BAY 60-4552), M3, and M4, V _ss volume of distribution at steady state