Table 2.

Riociguat exposure by smoking status (non-smokers compared with smokers and non-smokers combined) in healthy individuals and individuals with renal or hepatic impairment

	Median AUC∞,norm (kg·h/L)
	Non-smokers	Smokers and non-smokers
Renal impairment study [33]
Normal (CrCl > 80 mL/min)	22.0	21.4
Mild impairment (CrCl 50–80 mL/min)	40.4	33.9
Moderate impairment (CrCl 30–49 mL/min)	65.2	40.9
Severe impairment (CrCl < 30 mL/min)	40.4	33.6
Hepatic impairment study [32]
Mild impairment (Child–Pugh A)	43.3	32.7
Control A	30.2	30.2
Moderate impairment (Child–Pugh B)	39.4	36.3
Control B	31.5	30.5

AUC _∞,norm area under the plasma concentration–time curve from time zero to infinity divided by dose per kilogram body weight, CrCl creatinine clearance