Table 2.
Associations between genotypes of rs1880118 and levels of serum HDL-C and TC in multistage and combined analyses
| Data source | N | Race | BETA | SE | P |
|---|---|---|---|---|---|
| A (trait=HDL-C) | |||||
| Discovery | 1666 | Han Chinese | 0.066 | 0.019 | 4.0E-04 |
| Replication I | 3027 | Han Chinese | 0.032 | 0.010 | 1.6E-03 |
| Replication II | 2094 | Han Chinese | 0.038 | 0.012 | 1.6E-03 |
| Combined (Han Chinese) | 6787 | Han Chinese | 0.039 | 0.007 | 4.4E-08 |
| GLGC | 91033 | European ancestry | 0.022 | 0.006 | 1.6E-04 |
| Combined (All ancestries) | 97820 | All ancestries | 0.029 | 0.005 | 1.4E-10 |
| B (trait=TC) | |||||
| Discovery | 1665 | Han Chinese | 0.087 | 0.040 | 3.2E-02 |
| Replication I | 3025 | Han Chinese | 0.017 | 0.029 | 5.5E-01 |
| Replication II | 2094 | Han Chinese | 0.061 | 0.035 | 8.0E-02 |
| Combined (Han Chinese) | 6784 | Han Chinese | 0.047 | 0.019 | 1.6E-02 |
| GLGC | 91171 | European ancestry | 0.019 | 0.006 | 1.9E-03 |
| Combined (All ancestries) | 97955 | All ancestries | 0.022 | 0.006 | 2.1E-04 |
The minor allele (C allele) was considered as the effective allele in analyses. Beta and SE were calculated using a linear regression model adjusted for age and gender. The effects of rs1880118 were combined using fixed-effect model. No heterogeneities were observed
TC total cholesterol, HDL-C high-density lipoprotein cholesterol, N number of subjects, GLGC Global Lipids Genetics Consortium