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. 2018 May 23;11:168. doi: 10.3389/fnmol.2018.00168

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Copyright © 2018 Antonelli, Casciati, Tanori, Tanno, Linares-Vidal, Serra, Bellés, Pannicelli, Saran and Pazzaglia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shh pathway deregulation alters genes expression in key pathways in neurogenesis. (A) Each box contains genes showing altered expression in the DG of Ptch1^+/− male mice at 8 months of age. Arrows indicate direction of expression. A cut-off of 1.3 was applied for gene expression fold change. Altered genes are grouped in three categories: cell proliferation and differentiation, synaptic functions and growth factors and cytokines. (B) Predicted association between proteins based on observed patterns of simultaneous expression of genes. All deregulated genes were separately imported into STRING software.