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Shh pathway activation induces DG cells proliferation by increasing TLX and Cyclin D1 expression. (A) TLX mRNA relative expression in Ptch1+/− mice at 2 and 8 months of age. (B) Cyclin D1 relative expression in Ptch1+/− mice at 2 and 8 months. The number of mice used per test is indicated in the graphs (n). Data are reported as mean ± SEM *p < 0.05; **p < 0.01; ***p < 0.001 for comparison with controls (Student-t test).
