Table 1.
M18 full-length IgG3 and M18 IgG3 F(ab’)2 induced hemagglutination with different efficacy.
| Concentration (nM) | Score of hemagglutinationa | Concentration (nM) | Score of hemagglutination | ||
|---|---|---|---|---|---|
| Native IgG3 | F(ab’)2 obtained using IdeZ | Recombinant IgG3 | Recombinant F(ab’)2 | ||
| 82.5 | ++++ | + | 93 | ++++ | ± |
| 41.3 | ++++ | ± | 46.5 | ++++ | – |
| 20.6 | ++++ | – | 23.3 | ++++ | – |
| 10.3 | ++++ | – | 11.6 | +++ | – |
| 5.2 | +++ | – | 5.8 | +++ | – |
| 2.6 | +++ | – | 2.9 | + | – |
| 1.3 | ++ | – | 1.5 | ± | – |
| 0.6 | ± | – | 0.7 | – | – |
| 0.3 | – | – | 0.4 | – | – |
aRepresentative results of three independent experiments.