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Hemagglutination induced by the muteins with modified charge of the CH2 domain.
| M18 variants | O10 variants | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Conc. (μg/ml) | IgG1 | IgG3 | IgG1_CH2charge | IgG3_CH2charge | Conc. (μg/ml) | IgG1 | IgG3 | IgG1_CH2charge | IgG3_CH2charge |
| 5.00 | ±a | ++++ | – | +++ | 2.00 | – | ++++ | ± | ++++ |
| 2.50 | – | ++++ | – | +++ | 1.00 | – | +++ | – | +++ |
| 1.25 | – | +++ | – | ++ | 0.50 | – | ++ | – | ++ |
| 0.63 | – | ++ | – | ++ | 0.25 | – | ± | – | ± |
| 0.31 | – | + | – | ± | 0.13 | – | – | – | – |
| 0.16 | – | ± | – | – | 0.06 | – | – | – | – |
| 0.00 | – | – | – | – | 0.00 | – | – | – | – |
aRepresentative results of two independent experiments.
