Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 23;9:250. doi: 10.3389/fendo.2018.00250

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Carlberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Chromatin model of vitamin D signaling. Top: production of vitamin D₃ and its metabolites 25(OH)D₃ and 1,25(OH)₂D₃. Center: vitamin D receptor (VDR) (green) binds accessible genomic DNA in complex with a partner protein (RXR or others, blue). VDR’s DNA binding is supported by the pioneer factor PU.1 (purple). The genomic region that can be influenced by 1,25(OH)₂D₃ (via binding to VDR) is restricted by CTCF proteins (orange) defining left and right topologically associated domain (TAD) borders, i.e., only vitamin D target genes within the TAD will be stimulated to produce more mRNA copies. Bottom and right: schematic illustration of TAD size on relation to chromosomes and the nucleus.