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. 2018 May 23;9:1094. doi: 10.3389/fimmu.2018.01094

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Copyright © 2018 Díaz-Muñoz and Turner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of RNA-binding proteins (RBPs) in T- and B-cell development. Conditional mouse models have revealed the importance of the RBP ZFP36L1 and ZFP36L2 in cell quiescence upon VDJ recombination to test and positively select those cells that have successfully recombined the BCR and TCR. C-NOT3 is related to successful VDJ recombination. These three RBPs and ELAVL1 are implicated in later expansion of double negative (DN) 3–4 T cells. ELAVL1, ZFP36, Roquin, and Regnase-1 are implicated in activation and differentiation of single positive T cells. ZFP318 is involved in IgD expression in transitional T2 B cells. ZFP36L1 and LIN28b have been involved in marginal zone (MZ) B-cell differentiation. hnRNPC and ELAVL1 are implicated in follicular (FO) B-cell maintenance.