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. 2018 May 23;9:1094. doi: 10.3389/fimmu.2018.01094

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Copyright © 2018 Díaz-Muñoz and Turner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of post-transcriptional regulation upon T-cell activation. (A) Global regulation of RNA splicing upon T-cell activation. Splicing regulators (in blue) control alternative splicing and/or expression of T-cell receptor (CD25, CD62L, CD45), kinases (MKK7), paracaspases (MALT1), and cytokines (IL21) among other proteins. (B) CELF2-MKK7-JNK axis of enhanced TCR-mediated activation. (C) T-cell differentiation in modulated by the extension of MALT1 paracaspase activation, cleavage of Roquin and Regnase-1 RBP, and release repression of their mRNA targets.