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. 2018 May 29;8:8335. doi: 10.1038/s41598-018-26690-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neuronal coding adapts to stimulus history. (a,b) Firing rates of both LSO and MSO are modulated by recent stimulus history via a GABAergic feedback loop. Modified from Grothe and Pecka (2014) (c) Schematic of the Hemispheric Balanced Model including the effects of hemisperically specific adaptation: sound source azimuth is estimated based on a population vector analysis of MSO and low-frequency LSO for both hemispheres independently. The two estimates are then combined to yield a hemispherically balanced estimate of sound source location at the level of the midbrain.