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. 2018 May 29;8:8286. doi: 10.1038/s41598-018-26334-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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K13 sequencing as a proof-of-concept. We sequenced the whole K13 from 54 samples obtained in Indonesia. There are 61.1% samples with SNPs in 28 positions. A significant number of samples (42%) have SNPs in genomic position 1726696 of chromosome 13, which is in the region of K13. The respective K13 protein domains in regard to genomic positions is shown (A). The polymorphism in genomic position 1726696 is validated consistently with other sequencing means. An example of this validation with Sanger and/or Illumina is shown (B). Sequencing of PfCRT from 17 samples shows SNPs in 7 positions. We further found two haplotypes with most samples are of haplotype 1 (see Supplementary Figure 8B). The respective PfCRT protein domains in regard to genomic positions is also shown (C). All data are obtained from the sequencing of clinical specimens collected with FTA card and sequenced with flow cell R9.4.