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Zika virus epidemiology. The yellow area depicts the geographical distribution or landmarks of Zika virus. The virus was first isolated in Uganda from rhesus macaque monkey and Aedes africanus mosquito, followed by first isolation in human in 1954 in Nigeria. The subsequent circulations were restricted to Africa and Southeast Asia. In 2015, emergence of Zika virus in South America issued an alert to Pan American Health Organization (PAHO).
