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. 2018 May 23;9:519. doi: 10.3389/fphar.2018.00519

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Copyright © 2018 Zheng, Huang, Huang, Yang, Zhu, Wang, Wang, He, Ji, Wang, Qi, Liu and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SHK on cell proliferation and cell cycle arrest. (A) Chemical structure of SHK (MW = 288.3). (B) Cell viabilities of A549 and H1299 cells were measured by MTT assay after treatment with SHK (0–6 μM) for 24, 48, and 72 h. (C) EdU incorporation was evaluated after SHK treatments for 72 h, and mean EdU fluorescences in SHK treatments were relative to that in control treatment, which was arbitrarily set as 100. (D) Percentages of cell cycle arrest were analyzed by flow cytometry after SHK treatments. (E) Expression of Cyclin D1 in A549 and H1299 cells after SHK treatments. Data represent mean ± SD (n = 3). ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. Ctrl (control).

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