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. 2018 May 23;9:1132. doi: 10.3389/fimmu.2018.01132

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Copyright © 2018 Figueiredo, Azevedo, Mousdell, Resende-Lara, Ireland, Santos, Girola, Cunha, Schmid, Polonelli, Travassos and Mielgo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of the mechanism of action of the C36L1 peptide in macrophages (MOs) and dendritic cells (DCs). C36L1 binds to receptor of macrophage migration inhibitory factor (MIF) CD74, thereby blocking its immunosuppressive effect on MOs and DCs (A), restoring their antitumorigenic functions and their capacity to activate and support an effective immune response against metastatic melanoma (B).