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. 2018 May 29;8:8196. doi: 10.1038/s41598-018-26399-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Recommended organization strategy resulting in (left) maximum pathway flux or (right) minimum intermediate leakage for native Pdu metabolism as a function of (A) k_catE₀ of PduCDE and PduP/Q, (B) organelle permeability and K_M of PduP/Q, and (C) organelle permeability and cell membrane permeability. Regions of parameter space are colored by the optimal organization strategy in that region: organelle (blue); scaffold (orange); or no organization (grey). Baseline parameter values are shown with a black dashed line.