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. 2018 May 29;8:8256. doi: 10.1038/s41598-018-26653-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Onco-homologs in Class II. (a) Over-representation of onco-homologs across non-mammalian organism groups. The heatmap indicated statistical significance in the number between onco-homologs and random-site-extracted homologs (*P < 0.05, ***p < 0.01). (b) Protist onco-homolog Pyk2, D8M5N7aligned with its proto-oncogene BRAF. Green and red letter represented the wild-type and mutant amino acids in BRAF, respectively. (c) Domain organizations and onco-signatures of FLT3, isoforms of onco-homologs Btk29 in fly and human BTK.