FIG 7.

RBM4 functions in cortical lamination by modulating alternative splicing of Dab1. (Top) The diagram depicts the result of the experiment represented in Fig. 6A, showing the relative expression of RBM4, PTBP1, and PTBP2 throughout brain development (E12.5 was set to 1) and Dab1 mRNA and protein isoforms expressed at different stages. FL, full-length; 78 Dab1Δ78. (Bottom) The scheme illustrates the regulation of Dab1 exon 7/8 selection by the interplay between RBM4 and PTBP1/2 in the early and late stages of brain development; single exon (E7 or E8) selection is not depicted.