Figure 1.

A gene signature defining the naive state. Genes expressed in the primed and naive state in deep sequencing data from Takashima et al. [129] were compared (a) and the most relevant over-represented KEGG pathways exclusively in naive, primed and common in naive and primed are listed in (b). ECM, extracellular matrix. Genes exclusively expressed in the naive state were compared to genes expressed in the inner cell mass (ICM) from Adjaye et al. [134] (c) and are proposed as the marker signature of the naive state (d).