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. 2018 May 21;373(1750):20170221. doi: 10.1098/rstb.2017.0221

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© 2018 The Author(s)

Published by the Royal Society. All rights reserved.

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Figure 7. — Example of upstream regulator identification with Ingenuity Pathway Analysis (IPA) software. The analysis was conducted using levels of differentially expressed genes compared with levels in primary human hepatocytes (twofold cut-off, p < 0.05), in embryonic stem cells (ESC-MRC), induced-pluripotent stem cells (iPSC-CEL) and their corresponding HLCs (HLC MRC-D21 and iPSC HLC CEL). (a) The heatmap shows the −log(p-value) of the top 20 most significant upstream regulators. (b) The heatmap shows the activation z-score of the top 20 most significant upstream regulator stem cells and HLCs.