Table 1.
Microarray analysis showing dysregulated transcripts in KEGG pathways relevant to energy metabolism. Adj p-value = adjusted p-value (Benjamini–Hochberg correction).
| KEGG pathway | gene name | log2FC | Adj p-value |
|---|---|---|---|
| TCA cycle hsa00020 |
IDH2 | −0.285 | 0.004 |
| IDH3A | 0.271 | 0.017 | |
| MDH1 | −0.192 | 0.025 | |
| OGDHL | 0.360 | 0.001 | |
| SDHA | 0.236 | 0.045 | |
| PCK1 | 0.635 | 0.007 | |
| fatty acid degradation hsa00071 |
ACSL1 | 0.459 | 0.007 |
| CPT1A | 0.281 | 0.001 | |
| ACADM | 0.324 | 0.009 | |
| ACADVL | 0.727 | 0.000 | |
| ACAT1 | 0.213 | 0.008 | |
| ADH1A | −0.305 | 0.008 | |
| ALDH2 | −0.274 | 0.026 | |
| CYP4A11 | 0.814 | 0.008 | |
| oxidative phosphorylation hsa00190 |
NDUFB3 | −0.213 | 0.023 |
| SDHC | −0.252 | 0.031 | |
| SDHA | 0.236 | 0.045 | |
| UQCRC1 | 0.226 | 0.019 | |
| ATP5J2 | −0.225 | 0.013 | |
| ATP5I | −0.310 | 0.005 | |
| ATP6V0E2 | 0.308 | 0.005 | |
| ATP6V0D1 | −0.206 | 0.018 | |
| COX11 | 0.173 | 0.031 | |
| glycolysis/gluconeogenesis hsa00010 |
GLYCTK | −0.454 | 0.004 |
| AKR1A1 | −0.170 | 0.040 | |
| AKR1B10 | 1.139 | 0.000 | |
| PLPP2 | 0.385 | 0.006 | |
| CEL | −0.319 | 0.014 | |
| NAFLD hsa04932 |
LEP | −0.793 | 0.001 |
| CXCL8 | 0.772 | 0.043 | |
| CDC42 | −0.500 | 0.001 | |
| IRS2 | 0.485 | 0.001 | |
| CDC42 | −0.463 | 0.000 | |
| JUN | 0.427 | 0.009 | |
| PIK3R1 | −0.349 | 0.003 | |
| ADIPOR2 | 0.292 | 0.001 | |
| AKT1 | −0.193 | 0.017 | |
| ERN1 | 0.180 | 0.038 |