FIG 4 .

HRMS-based comparative metabolomics of AF293 (wild type [WT]) and A. fumigatus ICS mutants. (A to F) Extracted-ion chromatograms (EICs) corresponding to compounds 7 to 12 in the wild type grown with or without copper (orange and purple lines, respectively), in the ΔxanB, ΔcrmA, and ΔcrmCD mutants (blue, green, and red lines, respectively), the ΔxanB ΔcrmA double mutant under the copper-depleted condition (black lines), and the OE::xanC mutant with or without copper (black and red lines, respectively).