FIG 2.

IL-15 increases the cytotoxic function of NK cells. (A) (Left and middle) Degranulation of NK cells measured by CD107a expression after coculture with the cell line K562 or autologous HIV-superinfected CD4⁺ T cells (n = 21 and n = 8, respectively). (Right) IFN-γ production after coculture with K562 cells measured by intracellular staining (n = 17). Wilcoxon matched-pairs signed-rank test. (B) (Left and middle) Comparison between degranulation and IFN-γ production in NK cells from HIV-negative or HIV-positive donors. (Right) Fold change (IL-15/untreated) of CD107a expression and IFN-γ production in HIV-negative and HIV-positive donors. Mann-Whitney test. The orange circles correspond to cells from HIV-negative donors, and the purple squares correspond to cells from aviremic HIV-positive donors. The error bars indicate SEM.