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. 2018 May 29;92(12):e00247-18. doi: 10.1128/JVI.00247-18

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Copyright © 2018 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Stem antibody epitopes and sequences of different H5 HAs. (A) Stem antibody epitopes are conserved among different H5 HAs. (B) Residues in VN/1203 HA that differ from those in HA of at least two strains among CB/R0405050, GY/337, and ST/4690. (C) Stem antibody epitopes and different residues (shown in panel B) in VN/1203 HA trimer (PDB entry 2FK0). In panels A and C, the epitopes are indicated as follows: green, C179 epitopes; yellow, CR6261 epitopes; pink, FI6 epitopes. In panel C, the epitopes and residues are indicated as follows: blue, C179 and CR6261 overlap epitopes; cyan, CR6261 and FI6 overlap epitopes; sienna, residue 419 (HA2 number 89); black, different residues on HA1 shown in panel B. HK/156, A/Hong Kong/156/1997; VN/1203, A/Viet Nam/1203/2004; CB/R0405050, A/Cambodia/R0405050/2007; ID/5, A/Indonesia/5/2005; TK/1, A/turkey/Turkey/1/2005; HK/3088, A/gray heron/Hong Kong/3088/2007; AH/1, A/Anhui/1/2005; GX/13, A/duck/Guangxi/13/2004; OS/102, A/crow/Osaka/102/2004; HK/2986.1, A/duck/Hong Kong/2986.1/2000; GY/337, A/goose/Guiyang/337/2006; GX/1378, A/duck/Guangxi/1378/2004; HB/wg, A/duck/Hubei/wg/2002; VN/NCVD-016, A/chicken/Vietnam/NCVD-016/2008; HK/86.3, A/chicken/Hong Kong/86.3/2002; ST/4690, A/chukar/Shantou/4690/2003.