FIG 1.

Epitope-specific CTL response in VNPs and SPs. (a and b) Map of the specific overlapping epitopes that generated IFN-γ responses for VNPs and SPs, respectively. Data are presented as spot-forming cells (SFC) per 10⁶ PBMCs. Specifically, for VNPs we were able to compare samples from t₀ (light orange) with those from t₃ (dark orange). (c) Specific CTL response magnitude. The magnitude of the response was the additive response of all the positive wells measured as SFC/10⁶ PBMCs. VNP data are represented in light orange (t₀) or dark orange (t₃). SP data are presented in dark blue (t₃). (d) Specific CTL response breadth.