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. 2018 May 23;9:583. doi: 10.3389/fphys.2018.00583

Figure 2.

Figure 2

Presence of anti-contractile effects of PVAT in human mesenteric arteries and their inhibition by XE991. (A,B) Original recordings showing inhibition of the anti-contractile effects of PVAT by XE991 (30 μM). Recordings are shown in the presence (red curves) and absence (black curves) of XE991. XE991 had no effects on 5-HT contractions in (–) fat rings (A), but increased 5-HT contractions in (+) fat rings (B). (C) Concentration-response curves for 5-HT (0.01–100 μM) in (+) fat vessels in the presence (n = 13) and absence of XE991 (n = 15) and in (–) fat vessels in the presence (n = 10) and absence of XE991 (n = 10). *p < 0.05, p < 0.05 for (+) fat control vessels compared to all other groups each.