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. 2018 May 28;17:1533034618775509. doi: 10.1177/1533034618775509

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Overexpression of ROCK1 reverses the tumor suppressive effect of miR-199a in CRC cells. A, Exogenetic overexpression of ROCK1 partially rescues the miR-199a-induced suppression of cell proliferation in SW480 cells. B, Restoration of ROCK1 partially rescues the miR-199a-induced suppression of colony formation ability in SW480 cells. C, Restoration of ROCK1 partially attenuates the suppression of cell migration and invasion induced by miR-199a. D, Exogenetic overexpression of ROCK1 blocks the effect of miR-199a on apoptosis. E, Exogenetic overexpression of ROCK1 restores the miR-199a-induced suppression of expression of ROCK1 protein in SW480 cells. *P < .05. CRC indicates colorectal cancer; miR-199a, microRNA-199a; ROCK1, Rho-associated coiled coil-containing protein kinase 1.