Table 2.

Risk factor of gastric cancer development after Helicobacter pylori eradication

Ref.	Subject number	Study design	Diagnosis	Age	Follow-up period (yr)	Number of cancer	Risk factor
Shichijo et al[31]	573	Cohort study	CG/DU/GU	58	6.4	21	Endoscopic severe atrophy
							Histologic intestinal metaplasia
Take et al[32]	1674	Cohort study	GU/DU	51	5.6	28	Endoscopic severe atrophy
Toyoshima et al[55]	1232	Cohort study	CG/DU/GU	54	2.5	15	Endoscopic severe atrophy
Sakitani et al[56]	965	Cohort study	CG/DU/GU	63	4.5	21	Endoscopic severe atrophy
Cheung et al[57]	63397	Cohort study	Helicobacter pylori infection (GU 2%, DU 3%)	55	7.6	153	Proton pump inhibitor
Takata et al[58]	101	Cohort study	CG/GU/GC	56	5.3	8	Age
Kodama et al[59]	2355	Matched control study	CG/DU/GU/GC	63	4.1	21	Endoscopic severe atrophy
							OLGA staging
							Histologic atrophy at the antrum
							Histologic inflammation at the corpus
							Histologic intestinal metaplasia at the corpus
Sugimoto et al[60]	1200	Cross- sectional study	NA	70	4.6	79	Endoscopic severe atrophy
Haneda et al[62]	261	Cross sectional study	CG/DU/GU/GC/MALToma/hyperplastic polyp	57	NA	47	Pepsinogen I/II ratio ≤ 4.5
Maeda et al[63]	177	Cross sectional study	NA	NA	NA	94	Epigenetic marker

GU: Gastric ulcer; DU: Duodenal ulcer; CG: Chronic gastritis; GC: Gastric cancer; NA: Not available.