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. 2018 May 20;6(10):e13702. doi: 10.14814/phy2.13702

Figure 1.

Figure 1

Comparison of Model 1 and Model 2 experimental design. (A) In Model 1, injections of 0.9% saline were given to 11‐week‐old male CD‐1 mice for 7 days (SAL, n = 7) before breathing was quantified via unrestrained barometric plethysmography (URP). A control (CON, n = 11) group also had breathing quantified after 7 days, but no injections were given prior to this, and (B) In Model 2, CD‐1 mice also received 0.9% saline injections. The 17‐week‐old animals were initially tested through URP (PRE, n = 11) and then either given 1 day (POST1, n = 6) or 7 days (POST7, n = 5) of saline before undergoing another URP trial.