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. 2018 May 23;6(10):e13707. doi: 10.14814/phy2.13707

Figure 1.

Figure 1

Bilateral IRI (bIRI) was an appropriate model as AKI to CKD transition. (A) Level of serum creatinine (sCr) increased 1.55 ± 0.22 mg/dL 48 h after bilateral IRI (acute phase) compared with the sham group (*P < 0.05), then decreased 0.37 ± 0.07 mg/dL at day 28 (bIRI, n = 34; sham, n = 2; mean ± SD). (B) Masson trichrome staining of the kidney. bIRI‐induced tubulointerstitial fibrosis compared with the sham group both in the cortex and medulla (*P < 0.05). Tubulointerstitial fibrosis was severe in accordance with acute‐phase sCr (×40, scale bar = 500 μm) (bIRI, n = 34; sham, n = 2; mean ± SEM). (C) Relationship between acute‐phase sCr and tubulointerstitial fibrosis. A correlation was found between acute‐phase sCr level and the extent of tubulointerstitial fibrosis both in the cortex and medulla (bIRI, n = 34; sham, n = 2).