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. 2018 May 23;6(10):e13707. doi: 10.14814/phy2.13707

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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RS‐102895 reduced mRNA expression of CCR2 and M1 macrophage markers, but not M2 macrophage markers in ischemic left kidney. (A) mRNA expression of ischemic kidney. MCP‐1, CCR2, IL‐6, TNF‐α, iNOS, CD86, arginase 1, and CD206 mRNA expressions were measured. RS‐102895 reduced mRNA expression of CCR2, M1 macrophage markers, TNF‐α, iNOS, but not M2 macrophage markers, arginase 1, and CD206 (vehicle, RS‐102895; n = 6). (B) mRNA expression of the non‐ischemic right kidney. MCP‐1, CCR2, IL‐6, TNF‐α, iNOS, CD86, arginase 1, and CD206 mRNA expressions were measured in the contralateral non‐clamped right kidney. The expression of these markers was not different between the RS‐102895 and vehicle groups (vehicle, RS‐102895; n = 6).