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. 2017 Jan 20;28(3):974–987. doi: 10.1093/cercor/bhx005

Figure 8.

Figure 8.

Increasing endogenous NAAG stimulation of mGluR3 by iontophoresis of the glutamate carboxypeptidase II inhibitor, ZJ43, enhances Delay cell firing, and is reversed by 8-Bromo-cAMP. (A) Example of a Delay cell where ZJ43 had a linear, enhancing effect on neuronal firing. (B) The averaged neuronal firing rate (left) and d′ for neuronal firing (right) during the delay epoch for the population of Delay cells (n = 6) under Control, ZJ43@30 nA, and ZJ43@60 nA conditions, shown for the neurons’ preferred direction (solid line), and a representative nonpreferred direction (dashed line); mean ± SEM. Both doses significantly increased delay firing for the neuron's preferred direction and enhanced the neural representation of visual space as measured by d′. (C) Example of a Delay cell where 8-Bromo-cAMP reversed the enhancing effect of ZJ43 on neuronal firing. (D) The averaged neuronal firing rate (left) and d′ for neuronal firing (right) during the delay epoch for the population of Delay cells (n = 4) under Control, ZJ43@30 nA and ZJ43@30 nA + 8-Bromo-cAMP@10 nA conditions, shown for the neurons’ preferred direction (solid line), and a representative nonpreferred direction (dashed line); mean ± SEM. Co-iontophoresis of 8-Bromo-cAMP with ZJ43 reversed the enhancing effects of ZJ43 (30 nA) on Delay cell firing and spatial tuning. *P < 0.05, **P < 0.01 compared with Control condition; #P < 0.05 compared with ZJ43 alone.