Figure 5.
EAE symptom onset and severity following immunization with MOG peptide. Ten adult (6–8 weeks of age) female and male offspring from each exposure group were immunized with a CFA/MOG35–55 emulsion to induce EAE. Disease progression was monitored and scored every other day for 42 days. A, D, Kaplan Meier plots show the day of disease onset (disease score ≥1) in female (A) and male (D) offspring. B, E, The bar graphs depict the average day of onset for female (B) and male (E) developmentally exposed offspring. C, F, The average EAE disease score (±SEM) according to treatment group and day post immunization in female (C) and male (F) offspring. Disease scores were 0 = normal mouse, 1 = limp tail, 2 = limp tail and hind limb weakness, 3 = partial hind limb paralysis, 4 = complete hind limp paralysis, 5 = moribund. An * represents a p-value ≤ .05 compared with same sex control offspring.