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DOX aggravates oxidative damagein vitroandin vivo. (A) Intracellular ROS level in H9C2 cells treated by DOX. (B) The levels of MDA, SOD, GSH and GSH-PX in heart tissues of rats caused by DOX. (C) The levels of MDA, SOD, GSH and GSH-PX in heart tissues of mice caused by DOX. All data are expressed as the mean ± SD (n = 10). **p < 0.01 compared with control group.
