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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Neuropharmacology. 2018 Mar 15;135:192–201. doi: 10.1016/j.neuropharm.2018.03.016

Figure 1.

Figure 1

Synopsis of time course and experimental design of the study. Experiment 1: Study of the effect of RH on ischemic acidosis in ITD rats. Study groups were Naïve, ITD, and ITD + RH. Experiment 2: Study of the effect of inhibition of acidosis on ischemic injury in RH-exposed ITD rats. Study groups were ITD + RH, and ITD + RH + THAM. Experiment 3: Study of the effect of GLUT-inhibition on ischemic injury in RH-exposed ITD rats. Study groups were ITD + RH + Vehicle, and ITD + RH + GLUT inhibitor. ITD: insulin-treated diabetic, RH: recurrent hypoglycemia, THAM: Tris-(hydroxymethyl)-aminomethane.