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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Mucosal Immunol. 2017 Nov 29;11(3):581–589. doi: 10.1038/mi.2017.97

Figure 3. IL-17A and IL-17F in host defense and excessive inflammation.

Figure 3

In mice, deficient IL-17A- and IL-17F-mediated immunity predisposes to various pathogenic infections of the oral cavity, skin, intestine, lungs, and vagina, whereas excessive IL-17A- and IL-17F-mediated immunity induces pathological inflammation in the skin, intestine, and lungs. Human inborn errors of IL-17 immunity present chronic mucocutaenous candidiasis (CMC) in the oral cavity, CMC and staphylococcal diseases in the skin, and various bacterial infections in the lungs. Treatments with anti-IL-17A and IL-17RA inhibitors are beneficial for patients with psoriasis characterized by excessive inflammation in the skin.