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Schematic representation of progression from NAFLD/NASH to cirrhosis/HCC. The history of non-alcoholic fatty liver disease (NAFLD). This term assembles a wide spectrum of conditions ranging from dyslipidemia to steatohepatitis (NASH). Lifestyle factors, such as sedentary lifestyle and high calorie intake combined with insulin resistance and several others genetic and epigenetic factors induce the progression of NASH to cirrhosis and hepatocarcinoma (HCC) with its clinical consequences.
