Table 1. Changes in Type I Interferon genes mediated by cocaine.

Normal human astrocytes (NHA) were treated with escalating concentration of cocaine (0-10 μM) (Cooper et al., 2012; Jones et al., 2016; Swanson et al., 2011; Sweitzer and De Leo, 2011) in parallel to untreated astrocytes for 24 hr. The RT²PCR Profiler™ PCR Array Human Type I interferon Response was loaded with 100 ng/μL of cDNA. Gene targets from the Type I interferon array are included on the table, labeled by gene Accession number, gene abbreviation, gene name, other names used and their functions. Gene functions are described in the context of astrocytes or HIV-1 infection, when known. Two independent experiments were conducted and the average fold change for each gene following treatment with cocaine is described as fold change relative to control, from two independent experiments. The heat map describes the degree of fold change down or up.