Fig. 2.

Overview of the study design and effect of BLM instillation on weight gain in Atm-deficient mice (n ≥ 8) in comparison to wild-type mice (n ≥ 8). (a) 0.75 mg/kg body weight BLM or saline was given to Atm^-/- mice or Atm^+/+ control groups via the oropharyngeal route on day 0. On days 9 and 28, lung function tests, BAL and perfusion were performed. (b) Measurement of the body weight of Atm^+/+ mice and Atm^-/- mice at different time points (0–28 days) after BLM-induced lung injury. (c) Changes in body weights of Atm^+/+ and Atm^-/- mice on day 0 compared to the end of the observation period (d28). Data are expressed as the mean ±SEM. * P<0.05, ** P<0.01, *** P<0.001 compared to baseline. BAL = bronchoalveolar lavage, BLM = bleomycin.