Fig. 3.

Inflammation in Atm-deficient (Atm^-/-) and wild-type mice (Atm^+/+). (a) Total cells, (b-d) cell subsets and (e-g) cytometric bead analysis of pro-inflammatory cytokines (IL-6, CXLC1/KC and TNF-α) in bronchoalveolar lavage fluid (BALF) from Atm^-/- and Atm^+/+ mice before or 9 and 28 days after BLM administration. (h) Representative histological lung sections at 0, 9 and 28 days after the oropharyngeal instillation of saline or BLM in Atm^-/- and Atm^+/+ mice stained with haematoxylin and eosin. Data are expressed as the mean ±SEM. * compared to baseline, # compared Atm^-/- vs. Atm^+/+, * P<0.05, ** P<0.01, # P<0.05, ## P<0.01. BLM = bleomycin.