Fig. 6.
CR3 deficiency attenuates paraquat and maneb-induced NOX2 activation and microglial activationin vivo. (A) WT and CR3-/- mice were treated with P+M for 1 h and then the membrane translocation of p47phox was determined in midbrain tissues using Western blot. (B) The density of blots was quantified. (C) WT and CR3-/- mice were treated with P+M for 6 weeks. Microglia in the SN of mice were stained using Iba-1 antibody and the representative images were shown. (D) The density of Iba-1 staining was quantified. n = 4–5. *p < 0.05, **p < 0.01. Bar = 100 µm.