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. 2016 Dec 8;363(24):fnw275. doi: 10.1093/femsle/fnw275

Figure 2.

Figure 2.

Functional characterization of the cagPAI in H. pylori isolates from naturally infected rhesus macaques. All strains contained cagA (A) and expressed CagA in bacterial culture (B) and during co-culture with gastric epithelial cells (C). Each cagPAI encoded a functional T4SS as indicated by CagA phosphorylation (D) and IL-8 induction (E). Values of IL-8 induction are mean ± SEM from three biological replicates normalized to the results for H. pylori strain J166. *P < 0.05, **P < 0.01, ***P < 0.001 compared to H. pylori J166 cagY deletion mutant (ANOVA with Dunnett's test).