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. Author manuscript; available in PMC: 2018 Dec 7.
Published in final edited form as: ChemMedChem. 2017 Dec 4;12(23):2006–2013. doi: 10.1002/cmdc.201700626

Figure 1.

Figure 1

Live cell labeling with novel terpyridine derivative proligands. (A) Selection of proligands with a high maximum release and a low spontaneous release rate (%). U937 histocytoma cells were treated with a series of newly synthesized terpyridine proligands, and the index M/[(100 × S)/M] was determined for each compound. The index of 32 was 5091±96 (mean ± SD) and indicated as a dotted line. Compounds with the values greater than 5091±96 were indicated with asterisk. (B) Comparison of the spontaneous release rates of the compounds with the M/[(100 × S)/M] values being greater than that of 32. U937 cells were treated with compounds with the M/[(100 × S)/M] values greater than 5091±96. The spontaneous release and the maximum release values of each compound are depicted as bar graphs and the spontaneous release rates (%, mean ± SD) are indicated in the graphs. All experiments were performed in triplicate.