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. Author manuscript; available in PMC: 2018 Dec 7.
Published in final edited form as: ChemMedChem. 2017 Dec 4;12(23):2006–2013. doi: 10.1002/cmdc.201700626

Scheme 2.

Scheme 2

General procedure for the synthesis of 4′-O-substituted 2,2′:6′,2″-terpyridine-6,6′ ′-dicarboxylic acid. Diethyl 1′-hydro-4′-oxo-2,2′:6′,2″-terpyridine-6,6″-dicarboxylate was reacted with an electrophile in the presence of NaH in DMF for 15 h. Purification using SiO2 gel column chromatography afforded 4′-O-substituted diethyl 2,2′:6′,2″-terpyridine-6,6″-dicarboxylate derivative (Step-B). The product was hydrolyzed using NaOH to yield 4′-O-substituted 2,2′:6′,2″-terpyridine-6,6″-dicarboxylic acid (Step-C).