Presymptomatic |
No clinical motor signs or symptoms (Motor DCL = 0 or 1)
No cognitive signs or symptoms
May or may not have changes in imaging, quantitative motor assessments, or biomarkers
No symptomatic treatment indicated
Disease-modifying treatment when safe and available
|
Clinically At-Risk |
Prodromal HD |
Subtle motor signs (Motor DCL = 2)
AND/OR subtle cognitive signs or symptoms
Apathy, depression or other behavioral changes related to HD may be present
Usually changes in imaging and quantitative motor assessments
May need symptomatic treatment
Disease-modifying treatment appropriate
|
Clinically Prodromal HD |
Manifest HD |
Presence of clinical motor AND/OR cognitive signs and symptoms that have an impact on life
Functional changes, eg, decrease in TFC
Motor DCL = 3 or 4 (or Motor DCL of 2 if cognitive changes are significant AND there is evidence of progression)
Symptomatic treatment appropriate
Disease-modifying treatment appropriate
|
Clinically Manifest (requires Motor DCL = 4 and cognitive changes) |